Cross hepatotoxicity between tricyclic antidepressants.
نویسندگان
چکیده
Cross hepatotoxicity between drugs in very uncommon. We report the case of a patient in whom acute hepatitis was induced by a tricyclic antidepressant, amineptine, and recurred early after administration of another tricyclic antidepressant, clomipramine. This observation suggests that the tricyclic ring is involved in the mechanism of the deleterious effect of both drugs to the liver.
منابع مشابه
Antidepressant-induced liver injury: a review for clinicians.
OBJECTIVE Antidepressant drugs can cause drug-induced liver injury (DILI). The authors review clinical data relevant to antidepressant-induced liver injury and provide recommendations for clinical practice. METHOD A PubMed search was conducted for publications from 1965 onward related to antidepressant-induced liver injury. The search terms were "liver injury," "liver failure," "DILI," "hepat...
متن کاملCOMPARISON OF ANTIULCER EFFECTS OF TRICYCLIC ANTIDEPRESSANTS WITH CIMETIDINE AND OMEPRAZOLE IN RATS
The antiulcer effects of different tricyclic antidepressants (trimipramine, doxepin, imipramine, and amitriptyline) in comparison with those of cimetidine, pirenzepine and omeprazole were investigated in male rats with acute gastric ulcer. Acute gastric ulcer was induced by oral administration of O. 6N HCl solution, 1 mL/rat. Pretreatment of animals with doxepin, trimipramine, amitriptylin...
متن کاملMeta-analysis of Selective Serotonin Reuptake Inhibitors (SSRIs) Compared to Tricyclic Antidepressants (TCAs) in the Efficacy and Safety of Anti-depression Therapy in Parkinson᾽s Disease(PD) Patients
This meta-analysis aims to assess the efficacy and safety of SSRIs and TCAs in treatment of PD. A computer-base search was conducted of Pubmed, MEDLINE, EMBASE, Cochrane Controlled Trails Register (CCTR) up to December 2011. The random controlled clinic trials about SSRIs and TCAs in PD treatment were collected. Statistical analysis was completed using Review Manager, version 5.0. Five clinic c...
متن کاملMeta-analysis of Selective Serotonin Reuptake Inhibitors (SSRIs) Compared to Tricyclic Antidepressants (TCAs) in the Efficacy and Safety of Anti-depression Therapy in Parkinson᾽s Disease(PD) Patients
This meta-analysis aims to assess the efficacy and safety of SSRIs and TCAs in treatment of PD. A computer-base search was conducted of Pubmed, MEDLINE, EMBASE, Cochrane Controlled Trails Register (CCTR) up to December 2011. The random controlled clinic trials about SSRIs and TCAs in PD treatment were collected. Statistical analysis was completed using Review Manager, version 5.0. Five clinic c...
متن کاملAlteration of Serum Levels of Interlukin 1 and Tumor Necrosis Factor in Depression Independent of Treatment or Overdose of Tricyclic Antidepressants
Introduction: Pro-inflammatory cytokines, such as IL-1b and TNF- α have been suggested to be involved in the pathophysiology of depression. Tricyclic antidepressants (TCAs) are also thought to influence immune functions and concentrations of cytokines. The aim of this study was to evaluate the status of serum IL-1b and TNF-α in depressed patients who were treated, not treated, or poisoned wit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Gut
دوره 27 6 شماره
صفحات -
تاریخ انتشار 1986